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Biological and Environmental Research Ontology
| Preferred Name | Belimumab | |
| Synonyms |
|
|
| Definitions |
A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein (BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically recognizes and inhibits the biological activity of BlyS, thereby preventing the binding of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C91385 |
|
| Accepted_Therapeutic_Use_For |
Systemic Lupus Erythematosus
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| CAS_Registry |
356547-88-1
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|
| code |
C91385
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|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein (BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically recognizes and inhibits the biological activity of BlyS, thereby preventing the binding of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies.
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| Display_Name |
Belimumab
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|
| FDA_UNII_Code |
73B0K5S26A
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|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Belimumab
|
|
| Maps_To |
Belimumab
|
|
| NCI_Drug_Dictionary_ID |
680522
|
|
| PDQ_Closed_Trial_Search_ID |
680522
|
|
| PDQ_Open_Trial_Search_ID |
680522
|
|
| Preferred_Name |
Belimumab
|
|
| prefixIRI |
NCIT:C91385
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|
| prefLabel |
Belimumab
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor
|
|
| UMLS_CUI |
C1723401
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| subClassOf |
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