loading...| Preferred Name |
Belimumab |
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| Synonyms |
|
|
| Definitions |
A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein (BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically recognizes and inhibits the biological activity of BlyS, thereby preventing the binding of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C91385 |
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| Accepted_Therapeutic_Use_For |
Systemic Lupus Erythematosus |
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| CAS_Registry |
356547-88-1 |
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| code |
C91385 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein (BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically recognizes and inhibits the biological activity of BlyS, thereby preventing the binding of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies. |
|
| Display_Name |
Belimumab |
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| FDA_UNII_Code |
73B0K5S26A |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Belimumab |
|
| Maps_To |
Belimumab |
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| NCI_Drug_Dictionary_ID |
680522 |
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| PDQ_Closed_Trial_Search_ID |
680522 |
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| PDQ_Open_Trial_Search_ID |
680522 |
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| Preferred_Name |
Belimumab |
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| prefixIRI |
NCIT:C91385 |
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| prefLabel |
Belimumab |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor |
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| UMLS_CUI |
C1723401 |
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| subClassOf |