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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C91382
http://purl.obolibrary.org/obo/NCIT_C91382
|
|---|---|
| Preferred Name | Narnatumab |
| Definitions |
A fully human monoclonal antibody against RON (recepteur d'origine nantais; macrophage stimulating 1 receptor), with potential antineoplastic activity. Anti-RON monoclonal antibody IMC-RON8 binds to RON, thereby preventing binding of its ligand hepatocyte growth factor-like protein (HGFL or macrophage-stimulating protein (MSP)). This may prevent RON receptor-mediated signaling and may prevent cellular proliferation in tumor cells overexpressing RON. RON, a receptor tyrosine kinase, is overexpressed in a variety of epithelial cancer cell types and plays an important role in cellular proliferation, migration and invasion.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A fully human monoclonal antibody against RON (recepteur d'origine nantais; macrophage stimulating 1 receptor), with potential antineoplastic activity. Anti-RON monoclonal antibody IMC-RON8 binds to RON, thereby preventing binding of its ligand hepatocyte growth factor-like protein (HGFL or macrophage-stimulating protein (MSP)). This may prevent RON receptor-mediated signaling and may prevent cellular proliferation in tumor cells overexpressing RON. RON, a receptor tyrosine kinase, is overexpressed in a variety of epithelial cancer cell types and plays an important role in cellular proliferation, migration and invasion. |
|---|---|
| prefLabel | Narnatumab
|
| label | Narnatumab
|
| NCI_META_CUI | CL421584
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| PDQ_Closed_Trial_Search_ID | 673714
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| code | C91382
|
| prefixIRI | NCIT:C91382
|
| in_subset |
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| Display_Name | Narnatumab
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| Preferred_Name | Narnatumab
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| FDA_UNII_Code | R42YK40U9M
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Narnatumab
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| CAS_Registry | 1188275-92-4
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| NCI_Drug_Dictionary_ID | 673714
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 673714
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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