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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C913
http://purl.obolibrary.org/obo/NCIT_C913
|
|---|---|
| Preferred Name | Recombinant Tumor Necrosis Factor-Alpha |
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. Tumor necrosis factor-alpha binds to and activates "death receptors" on the cell surface, resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This agent also disrupts tumor vascularization. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. Tumor necrosis factor-alpha binds to and activates "death receptors" on the cell surface, resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This agent also disrupts tumor vascularization. (NCI04) |
|---|---|
| prefLabel | Recombinant Tumor Necrosis Factor-Alpha
|
| label | Recombinant Tumor Necrosis Factor-Alpha
|
| PDQ_Closed_Trial_Search_ID | 43225
|
| code | C913
|
| Has_Target | |
| prefixIRI | NCIT:C913
|
| in_subset | |
| Preferred_Name | Recombinant Tumor Necrosis Factor-Alpha
|
| FDA_UNII_Code | X2C8Z061MB
|
| Contributing_Source | FDA
|
| Maps_To | Recombinant Tumor Necrosis Factor-Alpha
|
| CAS_Registry | 308079-78-9
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| NSC Number | 697068
|
| NCI_Drug_Dictionary_ID | 43225
|
| Legacy Concept Name | Therapeutic_Tumor_Necrosis_Factor-Alpha
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43225
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1522669
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| Delete | Subject | Author | Type | Created |
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