Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C907
http://purl.obolibrary.org/obo/NCIT_C907
Preferred Name

Liothyronine
Definitions
A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)
prefLabel
Liothyronine
label
Liothyronine
Has_Salt_Form
CHEBI_ID
CHEBI:18258
PDQ_Closed_Trial_Search_ID
470233
code
C907
prefixIRI
NCIT:C907
in_subset
Preferred_Name
Liothyronine
FDA_UNII_Code
06LU7C9H1V
Contributing_Source
FDA
Chemical_Formula
C15H12I3NO4
CAS_Registry
6893-02-3
NSC Number
80203
NCI_Drug_Dictionary_ID
470233
Legacy Concept Name
Therapeutic_Triiodothyronine
type
subClassOf
PDQ_Open_Trial_Search_ID
470233
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C0041014
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