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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C90633
http://purl.obolibrary.org/obo/NCIT_C90633
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|---|---|
| Preferred Name | Mirabegron |
| Definitions |
An orally bioavailable agonist of the human beta-3 adrenergic receptor (ADRB3), with muscle relaxing, neuroprotective and potential antineoplastic activities. Upon oral administration, mirabegron binds to and activates ADRB3, which leads to smooth muscle relaxation. Mirabegron also restores sympathetic stimulation in mesenchymal stem cell (MSC) niches, inhibits JAK2-mutated hematopoietic stem cell (HSC) expansion and blocks the progression of myeloproliferative neoplasms (MPNs). Lack of sympathetic stimulation of the MSC and HSC niche is associated with the development of MPNs.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable agonist of the human beta-3 adrenergic receptor (ADRB3), with muscle relaxing, neuroprotective and potential antineoplastic activities. Upon oral administration, mirabegron binds to and activates ADRB3, which leads to smooth muscle relaxation. Mirabegron also restores sympathetic stimulation in mesenchymal stem cell (MSC) niches, inhibits JAK2-mutated hematopoietic stem cell (HSC) expansion and blocks the progression of myeloproliferative neoplasms (MPNs). Lack of sympathetic stimulation of the MSC and HSC niche is associated with the development of MPNs. |
|---|---|
| prefLabel | Mirabegron
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| label | Mirabegron
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| PDQ_Closed_Trial_Search_ID | 767328
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| code | C90633
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| prefixIRI | NCIT:C90633
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| in_subset | |
| Preferred_Name | Mirabegron
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| FDA_UNII_Code | MVR3JL3B2V
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| Contributing_Source | FDA
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| Chemical_Formula | C21H24N4O2S
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| Maps_To | Mirabegron
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| CAS_Registry | 223673-61-8
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| NCI_Drug_Dictionary_ID | 767328
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 767328
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| Accepted_Therapeutic_Use_For | Overactive bladder with symptoms of urge incontinence
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C2983812
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| Delete | Subject | Author | Type | Created |
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