Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C90591
http://purl.obolibrary.org/obo/NCIT_C90591
|
|---|---|
| Preferred Name | c-Met Inhibitor MK2461 |
| Definitions |
A selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor MK2461 preferentially inhibits activated c-Met in an ATP-competitive manner, thereby inhibiting its tyrosine kinase activity, which may inhibit c-Met signaling and result in cell growth inhibition in tumors that overexpress c-Met. c-Met, encoding the hepatocyte growth factor receptor (HGFR) tyrosine kinase, plays an important role in tumor cell proliferation and has been shown to be overexpressed or mutated in a variety of cancers.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor MK2461 preferentially inhibits activated c-Met in an ATP-competitive manner, thereby inhibiting its tyrosine kinase activity, which may inhibit c-Met signaling and result in cell growth inhibition in tumors that overexpress c-Met. c-Met, encoding the hepatocyte growth factor receptor (HGFR) tyrosine kinase, plays an important role in tumor cell proliferation and has been shown to be overexpressed or mutated in a variety of cancers. |
|---|---|
| prefLabel | c-Met Inhibitor MK2461
|
| label | c-Met Inhibitor MK2461
|
| PDQ_Closed_Trial_Search_ID | 560555
|
| code | C90591
|
| prefixIRI | NCIT:C90591
|
| in_subset | |
| Preferred_Name | c-Met Inhibitor MK2461
|
| Maps_To | c-Met Inhibitor MK2461
|
| NCI_Drug_Dictionary_ID | 560555
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 560555
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C2983789
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |