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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C90588
http://purl.obolibrary.org/obo/NCIT_C90588
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|---|---|
| Preferred Name | STAT3 Inhibitor OPB-31121 |
| Definitions |
An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. OPB-31121 inhibits the phosphorylation of STAT3, which prevents binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters and may result in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers, contributing to the loss of cell growth control and neoplastic transformation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. OPB-31121 inhibits the phosphorylation of STAT3, which prevents binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters and may result in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers, contributing to the loss of cell growth control and neoplastic transformation. |
|---|---|
| prefLabel | STAT3 Inhibitor OPB-31121
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| label | STAT3 Inhibitor OPB-31121
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| NCI_META_CUI | CL376190
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| PDQ_Closed_Trial_Search_ID | 570187
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| code | C90588
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| Has_Target | |
| prefixIRI | NCIT:C90588
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| in_subset |
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| Display_Name | STAT3 Inhibitor OPB-31121
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| Preferred_Name | STAT3 Inhibitor OPB-31121
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| Contributing_Source | CTRP
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| Maps_To | STAT3 Inhibitor OPB-31121
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| NCI_Drug_Dictionary_ID | 570187
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 570187
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| Semantic_Type | Pharmacologic Substance
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