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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C90583
http://purl.obolibrary.org/obo/NCIT_C90583
|
|---|---|
| Preferred Name | Anti-A33 Monoclonal Antibody KRN330 |
| Definitions |
A recombinant fully human monoclonal antibody directed against the human A33 antigen, with potential immunomodulatory and antineoplastic activity. Anti-A33 monoclonal antibody KRN330 recognizes and binds to the human A33 antigen, which may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against A33-positive colorectal cancers. A33 antigen, a 43 kDa transmembrane glycoprotein of the immunoglobulin superfamily, is highly and homogenously expressed in 95% of colorectal cancer cancers with only restricted expression in normal colonic mucosa and small bowel epithelia.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant fully human monoclonal antibody directed against the human A33 antigen, with potential immunomodulatory and antineoplastic activity. Anti-A33 monoclonal antibody KRN330 recognizes and binds to the human A33 antigen, which may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against A33-positive colorectal cancers. A33 antigen, a 43 kDa transmembrane glycoprotein of the immunoglobulin superfamily, is highly and homogenously expressed in 95% of colorectal cancer cancers with only restricted expression in normal colonic mucosa and small bowel epithelia. |
|---|---|
| prefLabel | Anti-A33 Monoclonal Antibody KRN330
|
| label | Anti-A33 Monoclonal Antibody KRN330
|
| PDQ_Closed_Trial_Search_ID | 584603
|
| code | C90583
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| Has_Target | |
| prefixIRI | NCIT:C90583
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| in_subset |
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| Display_Name | Anti-A33 Monoclonal Antibody KRN330
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| Preferred_Name | Anti-A33 Monoclonal Antibody KRN330
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| FDA_UNII_Code | A64J777I28
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-A33 Monoclonal Antibody KRN330
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| NCI_Drug_Dictionary_ID | 584603
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 584603
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C2983782
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