Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C90578
http://purl.obolibrary.org/obo/NCIT_C90578
Preferred Name

Isatuximab
Definitions
A humanized IgG1 monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. Isatuximab specifically binds to CD38 on CD38-positive tumor cells. This may trigger antitumoral antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and apoptosis eventually leading to cell lysis in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A humanized IgG1 monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. Isatuximab specifically binds to CD38 on CD38-positive tumor cells. This may trigger antitumoral antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and apoptosis eventually leading to cell lysis in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.
prefLabel
Isatuximab
label
Isatuximab
PDQ_Closed_Trial_Search_ID
668181
code
C90578
Has_Target
prefixIRI
NCIT:C90578
in_subset
Display_Name
Isatuximab
Preferred_Name
Isatuximab
FDA_UNII_Code
R30772KCU0
Contributing_Source
CTRP
FDA
Maps_To
Isatuximab
CAS_Registry
1461640-62-9
NCI_Drug_Dictionary_ID
668181
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
668181
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C2983777
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