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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C90567
http://purl.obolibrary.org/obo/NCIT_C90567
|
|---|---|
| Preferred Name | Parsatuzumab |
| Definitions |
A humanized IgG1 monoclonal antibody directed against the epidermal growth factor-like domain multiple 7 (EGFL7) with potential antineoplastic activity. Parsatuzumab binds to EGFL7, thereby preventing the activities of EGFL7 on endothelial cells and inhibiting the survival and migration of endothelial cells during angiogenesis. EGFL7, a vascular-restricted extracellular matrix protein which is upregulated during angiogenesis and which regulates vascular development, may be overexpressed on the cell surfaces of various solid tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized IgG1 monoclonal antibody directed against the epidermal growth factor-like domain multiple 7 (EGFL7) with potential antineoplastic activity. Parsatuzumab binds to EGFL7, thereby preventing the activities of EGFL7 on endothelial cells and inhibiting the survival and migration of endothelial cells during angiogenesis. EGFL7, a vascular-restricted extracellular matrix protein which is upregulated during angiogenesis and which regulates vascular development, may be overexpressed on the cell surfaces of various solid tumor cell types. |
|---|---|
| prefLabel | Parsatuzumab
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| label | Parsatuzumab
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| NCI_META_CUI | CL416251
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| PDQ_Closed_Trial_Search_ID | 646991
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| code | C90567
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| Has_Target | |
| prefixIRI | NCIT:C90567
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| in_subset |
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| Display_Name | Parsatuzumab
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| Preferred_Name | Parsatuzumab
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| FDA_UNII_Code | 435M4HCP2M
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Parsatuzumab
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| CAS_Registry | 1312797-14-0
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| NCI_Drug_Dictionary_ID | 646991
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 646991
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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