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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C90557
http://purl.obolibrary.org/obo/NCIT_C90557
|
|---|---|
| Preferred Name | Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205 |
| Definitions |
A small-molecule inhibitor of the human kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor 4SC-205 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein essential for the regulation of spindle dynamics, including assembly and maintenance, during mitosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule inhibitor of the human kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor 4SC-205 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein essential for the regulation of spindle dynamics, including assembly and maintenance, during mitosis. |
|---|---|
| prefLabel | Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205
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| label | Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205
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| NCI_META_CUI | CL416241
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| PDQ_Closed_Trial_Search_ID | 666188
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| code | C90557
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| prefixIRI | NCIT:C90557
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| in_subset | |
| Preferred_Name | Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205
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| Maps_To | Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205
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| NCI_Drug_Dictionary_ID | 666188
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 666188
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| Semantic_Type | Pharmacologic Substance
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