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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C90532
http://purl.obolibrary.org/obo/NCIT_C90532
|
|---|---|
| Preferred Name | Ensituximab |
| Definitions |
A chimeric monoclonal antibody against human colorectal and pancreatic carcinoma-associated antigens (CPAAs) with potential immunomodulating and anti-tumor activities. Anti-CPAA monoclonal antibody NPC-1C binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells. CPAAs, cell surface proteins, are upregulated on colon and pancreatic tumor cells. NPC-1C contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A chimeric monoclonal antibody against human colorectal and pancreatic carcinoma-associated antigens (CPAAs) with potential immunomodulating and anti-tumor activities. Anti-CPAA monoclonal antibody NPC-1C binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells. CPAAs, cell surface proteins, are upregulated on colon and pancreatic tumor cells. NPC-1C contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype. |
|---|---|
| prefLabel | Ensituximab
|
| label | Ensituximab
|
| NCI_META_CUI | CL413613
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| PDQ_Closed_Trial_Search_ID | 663436
|
| code | C90532
|
| Has_Target | |
| prefixIRI | NCIT:C90532
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| in_subset |
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| Display_Name | Ensituximab
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| Preferred_Name | Ensituximab
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| FDA_UNII_Code | F988K568V2
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Ensituximab
|
| CAS_Registry | 1092658-06-4
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| NCI_Drug_Dictionary_ID | 663436
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 663436
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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