Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C905 http://purl.obolibrary.org/obo/NCIT_C905
Preferred Name	Trifluridine
Definitions	A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity. (NCI04)
prefLabel	Trifluridine
label	Trifluridine
PDQ_Closed_Trial_Search_ID	39240
code	C905
Has_Target	http://purl.obolibrary.org/obo/NCIT_C17199
prefixIRI	NCIT:C905
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	Trifluridine
Preferred_Name	Trifluridine
FDA_UNII_Code	RMW9V5RW38
Contributing_Source	CTRP FDA
Chemical_Formula	C10H11F3N2O5
Maps_To	Trifluridine
CAS_Registry	70-00-8
NSC Number	75520
NCI_Drug_Dictionary_ID	39240
Legacy Concept Name	Trifluridine
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1557
PDQ_Open_Trial_Search_ID	39240
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI	C0040987

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