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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C898
http://purl.obolibrary.org/obo/NCIT_C898
|
|---|---|
| Preferred Name | Recombinant Transforming Growth Factor-Beta |
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and antineoplastic properties. TGF-beta may suppress tumor cell growth by decreasing the expression of cyclin D1, a cell cycle regulatory protein, and downregulating the expression of the oncogene c-myc. This agent is also involved in T cell-mediated immunosuppression by CD4+CD25+ T cells, which permits cancer cells to evade immune surveillance. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and antineoplastic properties. TGF-beta may suppress tumor cell growth by decreasing the expression of cyclin D1, a cell cycle regulatory protein, and downregulating the expression of the oncogene c-myc. This agent is also involved in T cell-mediated immunosuppression by CD4+CD25+ T cells, which permits cancer cells to evade immune surveillance. (NCI04) |
|---|---|
| prefLabel | Recombinant Transforming Growth Factor-Beta
|
| label | Recombinant Transforming Growth Factor-Beta
|
| code | C898
|
| prefixIRI | NCIT:C898
|
| in_subset | |
| Preferred_Name | Recombinant Transforming Growth Factor-Beta
|
| Maps_To | Recombinant Transforming Growth Factor-Beta
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| Legacy Concept Name | Therapeutic_Transforming_Growth_Factor-Beta
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Is_Related_To_Endogenous_Product | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1527196
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