loading...| Preferred Name | Recombinant Thyroid-Stimulating Hormone | |
| Synonyms |
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| Definitions |
A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C887 |
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| CAS_Registry |
9002-71-5 |
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| code |
C887 |
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| Contributing_Source |
FDA |
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| definition |
A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). |
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| FDA_UNII_Code |
02KSI6Z9AK |
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| in_subset | ||
| label |
Recombinant Thyroid-Stimulating Hormone |
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| Legacy Concept Name |
Recombinant_Thyroid-Stimulating_Hormone |
|
| NCI_Drug_Dictionary_ID |
526653 |
|
| PDQ_Closed_Trial_Search_ID |
526653 |
|
| PDQ_Open_Trial_Search_ID |
526653 |
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| Preferred_Name |
Recombinant Thyroid-Stimulating Hormone |
|
| prefixIRI |
NCIT:C887 |
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| prefLabel |
Recombinant Thyroid-Stimulating Hormone |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C1535531 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000526653 | PDQ | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C887 | NCIT | LOOM |