Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Recombinant Thyroid-Stimulating Hormone
Synonyms
Definitions

A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).
ID

http://purl.obolibrary.org/obo/NCIT_C887
CAS_Registry

9002-71-5
code

C887
Contributing_Source

FDA
definition

A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).
FDA_UNII_Code

02KSI6Z9AK
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424
label

Recombinant Thyroid-Stimulating Hormone
Legacy Concept Name

Recombinant_Thyroid-Stimulating_Hormone
NCI_Drug_Dictionary_ID

526653
PDQ_Closed_Trial_Search_ID

526653
PDQ_Open_Trial_Search_ID

526653
Preferred_Name

Recombinant Thyroid-Stimulating Hormone
prefixIRI

NCIT:C887
prefLabel

Recombinant Thyroid-Stimulating Hormone
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C1535531
subClassOf

http://purl.obolibrary.org/obo/NCIT_C2348
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