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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Benralizumab | |
| Synonyms |
|
|
| Definitions |
An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C88594 |
|
| Accepted_Therapeutic_Use_For |
Asthma
|
|
| CAS_Registry |
1044511-01-4
|
|
| code |
C88594
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma.
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|
| Display_Name |
Benralizumab
|
|
| FDA_UNII_Code |
71492GE1FX
|
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Benralizumab
|
|
| NCI_Drug_Dictionary_ID |
794137
|
|
| PDQ_Closed_Trial_Search_ID |
794137
|
|
| PDQ_Open_Trial_Search_ID |
794137
|
|
| Preferred_Name |
Benralizumab
|
|
| prefixIRI |
NCIT:C88594
|
|
| prefLabel |
Benralizumab
|
|
| Semantic_Type |
Pharmacologic Substance Immunologic Factor
|
|
| UMLS_CUI |
C2982078
|
|
| subClassOf |
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