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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C88335
http://purl.obolibrary.org/obo/NCIT_C88335
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|---|---|
| Preferred Name | Archexin |
| Definitions |
A 20-mer antisense oligodeoxynucleotide (ODN) against the proto-oncogene Akt with potential antineoplastic activity. Akt-1 antisense oligonucleotide RX-0201 binds to Akt-1 mRNA, inhibiting translation of the transcript; suppression of Akt-1 expression may result in the inhibition of cellular proliferation and the induction of apoptosis in tumor cells that overexpress Akt-1. Akt-1 is a serine-threonine protein kinase that stimulates proliferation and inhibits apoptosis of tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 20-mer antisense oligodeoxynucleotide (ODN) against the proto-oncogene Akt with potential antineoplastic activity. Akt-1 antisense oligonucleotide RX-0201 binds to Akt-1 mRNA, inhibiting translation of the transcript; suppression of Akt-1 expression may result in the inhibition of cellular proliferation and the induction of apoptosis in tumor cells that overexpress Akt-1. Akt-1 is a serine-threonine protein kinase that stimulates proliferation and inhibits apoptosis of tumor cells. |
|---|---|
| prefLabel | Archexin
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| label | Archexin
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| NCI_META_CUI | CL413599
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| PDQ_Closed_Trial_Search_ID | 662321
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| code | C88335
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| prefixIRI | NCIT:C88335
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| in_subset | |
| Preferred_Name | Archexin
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| FDA_UNII_Code | 4TEW51C830
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| Contributing_Source | FDA
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| Chemical_Formula | C194H228N70O103P19S19
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| Maps_To | Archexin
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| NCI_Drug_Dictionary_ID | 662321
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 662321
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| Delete | Subject | Author | Type | Created |
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