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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C88333
http://purl.obolibrary.org/obo/NCIT_C88333
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|---|---|
| Preferred Name | Gamma-Secretase Inhibitor RO4929097 |
| Definitions |
An orally bioavailable, small-molecule gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, small-molecule gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth. |
|---|---|
| prefLabel | Gamma-Secretase Inhibitor RO4929097
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| label | Gamma-Secretase Inhibitor RO4929097
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| PDQ_Closed_Trial_Search_ID | 662240
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| code | C88333
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| Has_Target | |
| prefixIRI | NCIT:C88333
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| in_subset |
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| Display_Name | Gamma-Secretase Inhibitor RO4929097
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| Preferred_Name | Gamma-Secretase Inhibitor RO4929097
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| FDA_UNII_Code | KK8645V7LE
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Gamma-Secretase Inhibitor RO4929097
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| CAS_Registry | 847925-91-1
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| NCI_Drug_Dictionary_ID | 662240
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It blocks certain enzymes that are needed for cell growth. This may slow the growth of cancer cells. It may also decrease the growth of new blood vessels that tumors need to grow. It is a type of gamma-secretase inhibitor and a type of Notch signaling inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 662240
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2742210
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