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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C88316
http://purl.obolibrary.org/obo/NCIT_C88316
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|---|---|
| Preferred Name | CDC7 Kinase Inhibitor NMS-1116354 |
| Definitions |
An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor NMS-1116354 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 initiates DNA replication by phosphorylating MCM2 (minichromosome maintenance complex component 2) at Ser40 and Ser53.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor NMS-1116354 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 initiates DNA replication by phosphorylating MCM2 (minichromosome maintenance complex component 2) at Ser40 and Ser53. |
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| prefLabel | CDC7 Kinase Inhibitor NMS-1116354
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| label | CDC7 Kinase Inhibitor NMS-1116354
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| NCI_META_CUI | CL413571
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| PDQ_Closed_Trial_Search_ID | 660731
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| code | C88316
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| Has_Target | |
| prefixIRI | NCIT:C88316
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| in_subset |
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| Display_Name | CDC7 Kinase Inhibitor NMS-1116354
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| Preferred_Name | CDC7 Kinase Inhibitor NMS-1116354
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| Contributing_Source | CTRP
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| Maps_To | CDC7 Kinase Inhibitor NMS-1116354
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| NCI_Drug_Dictionary_ID | 660731
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 660731
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| Semantic_Type | Pharmacologic Substance
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