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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C88303
http://purl.obolibrary.org/obo/NCIT_C88303
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|---|---|
| Preferred Name | Pexidartinib |
| Definitions |
A small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis. |
|---|---|
| prefLabel | Pexidartinib
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| label | Pexidartinib
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| Has_Salt_Form | |
| code | C88303
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| Has_Target | |
| prefixIRI | NCIT:C88303
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| in_subset |
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| Display_Name | Pexidartinib
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| Preferred_Name | Pexidartinib
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| FDA_UNII_Code | 6783M2LV5X
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Pexidartinib
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| CAS_Registry | 1029044-16-3
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2981820
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