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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C88286
http://purl.obolibrary.org/obo/NCIT_C88286
|
|---|---|
| Preferred Name | Pegylated Recombinant Human Arginase I BCT-100 |
| Definitions |
A recombinant human arginase I (liver arginase) covalently attached, via a succinamide propionic acid (SPA) linker, to a polyethylene glycol (PEG) of molecular weight 5,000 [rhArg-peg(5,000mw)] with potential antineoplastic activity. Upon intravenous administration of pegylated recombinant human arginase I BCT-100, arginase metabolizes the amino acid arginine to ornithine and urea, depleting intracellular arginine, which may inhibit proliferation of cells that are auxotrophic for arginine such as hepatocellular carcinoma (HCC) cells. This agent may also work synergistically with various cytotoxic agents.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant human arginase I (liver arginase) covalently attached, via a succinamide propionic acid (SPA) linker, to a polyethylene glycol (PEG) of molecular weight 5,000 [rhArg-peg(5,000mw)] with potential antineoplastic activity. Upon intravenous administration of pegylated recombinant human arginase I BCT-100, arginase metabolizes the amino acid arginine to ornithine and urea, depleting intracellular arginine, which may inhibit proliferation of cells that are auxotrophic for arginine such as hepatocellular carcinoma (HCC) cells. This agent may also work synergistically with various cytotoxic agents. |
|---|---|
| prefLabel | Pegylated Recombinant Human Arginase I BCT-100
|
| label | Pegylated Recombinant Human Arginase I BCT-100
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| NCI_META_CUI | CL413535
|
| PDQ_Closed_Trial_Search_ID | 657226
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| code | C88286
|
| prefixIRI | NCIT:C88286
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| in_subset | |
| Preferred_Name | Pegylated Recombinant Human Arginase I BCT-100
|
| FDA_UNII_Code | S3HC6XX81X
|
| Contributing_Source | FDA
|
| Maps_To | Pegylated Recombinant Human Arginase I BCT-100
|
| CAS_Registry | 1433787-75-7
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| NCI_Drug_Dictionary_ID | 657226
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 657226
|
| Semantic_Type | Pharmacologic Substance
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