Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C88270
http://purl.obolibrary.org/obo/NCIT_C88270
Preferred Name

Omipalisib
Definitions
A small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. Omipalisib binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. Omipalisib binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
prefLabel
Omipalisib
label
Omipalisib
PDQ_Closed_Trial_Search_ID
655580
code
C88270
Has_Target
prefixIRI
NCIT:C88270
in_subset
Display_Name
Omipalisib
Preferred_Name
Omipalisib
FDA_UNII_Code
1X8F5A3NA0
Contributing_Source
CTRP
FDA
Maps_To
Omipalisib
CAS_Registry
1086062-66-9
NCI_Drug_Dictionary_ID
655580
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
655580
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C2981793
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