loading...| Preferred Name |
Ferumoxytol |
|
| Synonyms |
|
|
| Definitions |
A superparamagnetic iron oxide nanoparticle coated with a low molecular weight semi-synthetic carbohydrate, polyglucose sorbitol carboxymethyl ether, with potential anti-anemic and imaging properties. After intravenous administration, ferumoxytol replaces iron stores with fewer side effects compared to the use of oral iron. In addition, this agent generates T1 relaxation, producing a magnetic field and enhancing T2 relaxation, thereby darkening contrast media-containing structures in magnetic resonance imaging (MRI). Due to small particle size, ferumoxytol remains in the intravasculature for a prolonged period and so may be used as a blood pool agent. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C87701 |
|
| Accepted_Therapeutic_Use_For |
Iron deficiency anemia |
|
| ALT_DEFINITION |
A nanoparticle form of iron made in the laboratory that is being studied for use in iron replacement therapy, and as a contrast agent for magnetic resonance imaging. Contrast agents are substances that are injected into the body and taken up by certain tissues, making the tissues easier to see in imaging scans. |
|
| CAS_Registry |
1309-38-2 |
|
| CHEBI_ID |
CHEBI:46726 |
|
| Chemical_Formula |
3Fe.4O |
|
| code |
C87701 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A superparamagnetic iron oxide nanoparticle coated with a low molecular weight semi-synthetic carbohydrate, polyglucose sorbitol carboxymethyl ether, with potential anti-anemic and imaging properties. After intravenous administration, ferumoxytol replaces iron stores with fewer side effects compared to the use of oral iron. In addition, this agent generates T1 relaxation, producing a magnetic field and enhancing T2 relaxation, thereby darkening contrast media-containing structures in magnetic resonance imaging (MRI). Due to small particle size, ferumoxytol remains in the intravasculature for a prolonged period and so may be used as a blood pool agent. |
|
| Display_Name |
Ferumoxytol |
|
| FDA_UNII_Code |
CLH5FT6412 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Ferumoxytol |
|
| NCI_Drug_Dictionary_ID |
377345 |
|
| PDQ_Closed_Trial_Search_ID |
377345 |
|
| PDQ_Open_Trial_Search_ID |
377345 |
|
| Preferred_Name |
Ferumoxytol |
|
| prefixIRI |
NCIT:C87701 |
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| prefLabel |
Ferumoxytol |
|
| Semantic_Type |
Inorganic Chemical Indicator, Reagent, or Diagnostic Aid |
|
| UMLS_CUI |
C2718747 |
|
| subClassOf |