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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C877
http://purl.obolibrary.org/obo/NCIT_C877
|
|---|---|
| Preferred Name | Thioinosine |
| Definitions |
A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de novo purine synthesis and perturbs the pool of nucleotides necessary for DNA replication. As a result, this agent inhibits DNA synthesis, blocks cellular proliferation and induces apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de novo purine synthesis and perturbs the pool of nucleotides necessary for DNA replication. As a result, this agent inhibits DNA synthesis, blocks cellular proliferation and induces apoptosis. |
|---|---|
| prefLabel | Thioinosine
|
| label | Thioinosine
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| PDQ_Closed_Trial_Search_ID | 39496
|
| code | C877
|
| prefixIRI | NCIT:C877
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| in_subset | |
| Preferred_Name | Thioinosine
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| FDA_UNII_Code | 46S541971T
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| Contributing_Source | FDA
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| Chemical_Formula | C10H12N4O4S
|
| Maps_To | Thioinosine
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| CAS_Registry | 574-25-4
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| NSC Number | 4911
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| NCI_Drug_Dictionary_ID | 39496
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| Legacy Concept Name | Thioinosine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39496
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0039904
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| Delete | Subject | Author | Type | Created |
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