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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C876
http://purl.obolibrary.org/obo/NCIT_C876
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|---|---|
| Preferred Name | Thioguanine |
| Definitions |
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04) |
|---|---|
| prefLabel | Thioguanine
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| label | Thioguanine
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| PDQ_Closed_Trial_Search_ID | 43669
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| code | C876
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| prefixIRI | NCIT:C876
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| in_subset |
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| Display_Name | Thioguanine
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| Preferred_Name | Thioguanine
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| FDA_UNII_Code | FTK8U1GZNX
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C5H5N5S.H2O
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| Maps_To | Thioguanine
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| CAS_Registry |
154-42-7
5580-03-0
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| NSC Number | 752
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| NCI_Drug_Dictionary_ID | 43669
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| Legacy Concept Name | Thioguanine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antimetabolites.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43669
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| Accepted_Therapeutic_Use_For | Acute nonlymphocytic leukemia
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0039902
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