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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C87288
http://purl.obolibrary.org/obo/NCIT_C87288
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|---|---|
| Preferred Name | Vinzolidine Sulfate |
| Definitions |
The sulfate salt of vinzolidine, an orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sulfate salt of vinzolidine, an orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase. |
|---|---|
| prefLabel | Vinzolidine Sulfate
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| label | Vinzolidine Sulfate
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| code | C87288
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| prefixIRI | NCIT:C87288
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| in_subset | |
| Preferred_Name | Vinzolidine Sulfate
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| FDA_UNII_Code | 78NZ2PMP25
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| Contributing_Source | FDA
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| Chemical_Formula | C48H58ClN5O9.H2O4S
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| Maps_To | Vinzolidine Sulfate
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| CAS_Registry | 67699-41-6
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2828244
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