Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C869 http://purl.obolibrary.org/obo/NCIT_C869
Preferred Name	Thalicarpine
Definitions	A natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. (NCI04)
prefLabel	Thalicarpine
label	Thalicarpine
CHEBI_ID	CHEBI:9509
PDQ_Closed_Trial_Search_ID	39712
code	C869
prefixIRI	NCIT:C869
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Thalicarpine
FDA_UNII_Code	8X1D791RF6
Contributing_Source	FDA
Chemical_Formula	C41H48N2O8
Maps_To	Thalicarpine
CAS_Registry	5373-42-2
NSC Number	68075
NCI_Drug_Dictionary_ID	39712
Legacy Concept Name	Thalicarpine
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C932 http://purl.obolibrary.org/obo/NCIT_C67422
PDQ_Open_Trial_Search_ID	39712
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C0039735

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