Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C866
http://purl.obolibrary.org/obo/NCIT_C866
Preferred Name

Tetradecanoylphorbol Acetate
Definitions
A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)
prefLabel
Tetradecanoylphorbol Acetate
label
Tetradecanoylphorbol Acetate
CHEBI_ID
CHEBI:37537
PDQ_Closed_Trial_Search_ID
43661
code
C866
prefixIRI
NCIT:C866
in_subset
Display_Name
Tetradecanoylphorbol Acetate
Preferred_Name
Tetradecanoylphorbol Acetate
FDA_UNII_Code
NI40JAQ945
Contributing_Source
CTRP
FDA
Chemical_Formula
C36H56O8
Maps_To
Tetradecanoylphorbol Acetate
CAS_Registry
16561-29-8
NSC Number
262244
NCI_Drug_Dictionary_ID
43661
Legacy Concept Name
Tetradecanoylphorbol_Acetate
type
ALT_DEFINITION
A substance being studied in the treatment of leukemias and lymphomas. It is also being studied in the treatment of other types of cancer. Tetradecanoylphorbol acetate affects many cell actions and may cause tumor cells to die. It is a type of phorbol ester.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
43661
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0039654
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