Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Therapeutic Testosterone
Synonyms
Definitions

A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.
ID

http://purl.obolibrary.org/obo/NCIT_C862
Accepted_Therapeutic_Use_For

Delayed puberty, male; Hypogonadism; Metastatic mammary cancer
CAS_Registry

58-22-0
CHEBI_ID

CHEBI:17347
Chemical_Formula

C19H28O2
code

C862
Contributing_Source

CTRP

FDA
definition

A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.
Display_Name

Therapeutic Testosterone
FDA_UNII_Code

3XMK78S47O
Has_Target

http://purl.obolibrary.org/obo/NCIT_C17063
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978
Is_Related_To_Endogenous_Product

http://purl.obolibrary.org/obo/NCIT_C2299
label

Therapeutic Testosterone
Legacy Concept Name

Therapeutic_Testosterone
NCI_Drug_Dictionary_ID

42926
NCI_META_CUI

CL1379971
NSC Number

9700
PDQ_Closed_Trial_Search_ID

42926
PDQ_Open_Trial_Search_ID

42926
Preferred_Name

Therapeutic Testosterone
prefixIRI

NCIT:C862
prefLabel

Therapeutic Testosterone
Semantic_Type

Organic Chemical

Pharmacologic Substance
subClassOf

http://purl.obolibrary.org/obo/NCIT_C2360

http://purl.obolibrary.org/obo/NCIT_C243
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