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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C857
http://purl.obolibrary.org/obo/NCIT_C857
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|---|---|
| Preferred Name | Teniposide |
| Definitions |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04) |
|---|---|
| prefLabel | Teniposide
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| label | Teniposide
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| PDQ_Closed_Trial_Search_ID | 43671
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| code | C857
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| Has_Target | |
| prefixIRI | NCIT:C857
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| in_subset |
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| Display_Name | Teniposide
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| Preferred_Name | Teniposide
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| FDA_UNII_Code | 957E6438QA
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C32H32O13S
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| Maps_To | Teniposide
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| CAS_Registry | 29767-20-2
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| NSC Number | 122819
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| NCI_Drug_Dictionary_ID | 43671
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| Legacy Concept Name | Teniposide
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| type | |
| ALT_DEFINITION | An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43671
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0039512
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