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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C85486
http://purl.obolibrary.org/obo/NCIT_C85486
|
|---|---|
| Preferred Name | Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111 |
| Definitions |
A bispecific monoclonal antibody directed against the human epidermal growth factor receptors ErbB2 (Her2) and ErbB3 (Her3) with potential antineoplastic activity. The anti-ErB2 targeting arm of anti-ErbB2/anti-ErbB3 bispecific monoclonal antibody MM-111 binds to ErbB2 on tumor cells with high affinity while the anti-Erb3 therapeutic arm binds to ErbB3, which may result in the inhibition of cellular proliferation and differentiation in ErbB2-overexpressing tumor cells via inhibition of ErbB3-dependent signal transduction pathways. ErbB2 and ErB3 are members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and are frequently overexpressed in solid tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific monoclonal antibody directed against the human epidermal growth factor receptors ErbB2 (Her2) and ErbB3 (Her3) with potential antineoplastic activity. The anti-ErB2 targeting arm of anti-ErbB2/anti-ErbB3 bispecific monoclonal antibody MM-111 binds to ErbB2 on tumor cells with high affinity while the anti-Erb3 therapeutic arm binds to ErbB3, which may result in the inhibition of cellular proliferation and differentiation in ErbB2-overexpressing tumor cells via inhibition of ErbB3-dependent signal transduction pathways. ErbB2 and ErB3 are members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and are frequently overexpressed in solid tumors. |
|---|---|
| prefLabel | Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111
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| label | Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111
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| PDQ_Closed_Trial_Search_ID | 647542
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| code | C85486
|
| Has_Target | |
| prefixIRI | NCIT:C85486
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| in_subset |
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| Display_Name | Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111
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| Preferred_Name | Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111
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| FDA_UNII_Code | 6IJ4CQY76O
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111
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| CAS_Registry | 1361108-53-3
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| NCI_Drug_Dictionary_ID | 647542
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 647542
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C2830144
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