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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C85469
http://purl.obolibrary.org/obo/NCIT_C85469
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|---|---|
| Preferred Name | pan-PI3K/mTOR Inhibitor SF1126 |
| Definitions |
A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival. |
|---|---|
| prefLabel | pan-PI3K/mTOR Inhibitor SF1126
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| label | pan-PI3K/mTOR Inhibitor SF1126
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| PDQ_Closed_Trial_Search_ID | 644818
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| code | C85469
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| Has_Target | |
| prefixIRI | NCIT:C85469
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| in_subset |
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| Display_Name | pan-PI3K/mTOR Inhibitor SF1126
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| Preferred_Name | pan-PI3K/mTOR Inhibitor SF1126
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| FDA_UNII_Code | DL0Q912033
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| Contributing_Source |
CTRP
FDA
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| Maps_To | pan-PI3K/mTOR Inhibitor SF1126
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| CAS_Registry | 936487-67-1
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| NCI_Drug_Dictionary_ID | 644818
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 644818
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2351370
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