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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C85454
http://purl.obolibrary.org/obo/NCIT_C85454
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|---|---|
| Preferred Name | Onalespib |
| Definitions |
A synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins. |
|---|---|
| prefLabel | Onalespib
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| label | Onalespib
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| PDQ_Closed_Trial_Search_ID | 642817
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| code | C85454
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| prefixIRI | NCIT:C85454
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| in_subset |
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| Display_Name | Onalespib
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| Preferred_Name | Onalespib
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| FDA_UNII_Code | Q7Y33N57ZZ
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Onalespib
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| CAS_Registry | 912999-49-6
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| NCI_Drug_Dictionary_ID | 642817
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 642817
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2975147
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