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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C853
http://purl.obolibrary.org/obo/NCIT_C853
|
|---|---|
| Preferred Name | Suramin |
| Definitions |
A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04) |
|---|---|
| prefLabel | Suramin
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| label | Suramin
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:45906
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| PDQ_Closed_Trial_Search_ID | 40052
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| code | C853
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| Has_Target | |
| prefixIRI | NCIT:C853
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| in_subset |
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| Display_Name | Suramin
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| Preferred_Name | Suramin
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| FDA_UNII_Code | 6032D45BEM
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C51H40N6O23S6
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| Maps_To | Suramin
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| CAS_Registry | 145-63-1
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| NCI_Drug_Dictionary_ID | 40052
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| Legacy Concept Name | Suramin
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| type | |
| ALT_DEFINITION | A drug that is used to treat infections caused by parasites. It is also being studied in the treatment of cancer. It belongs to the families of drugs called antiprotozoals and anthelmintics.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40052
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| Accepted_Therapeutic_Use_For | Trypanosomiasis; hormone-refractory prostate cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0038880
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