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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C850
http://purl.obolibrary.org/obo/NCIT_C850
|
|---|---|
| Preferred Name | Sulindac |
| Definitions |
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04) |
|---|---|
| prefLabel | Sulindac
|
| label | Sulindac
|
| CHEBI_ID | CHEBI:9352
|
| PDQ_Closed_Trial_Search_ID | 41538
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| code | C850
|
| Has_Target | |
| prefixIRI | NCIT:C850
|
| in_subset |
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| Display_Name | Sulindac
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| Preferred_Name | Sulindac
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| FDA_UNII_Code | 184SNS8VUH
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C20H17FO3S
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| Maps_To | Sulindac
|
| CAS_Registry | 38194-50-2
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| NCI_Drug_Dictionary_ID | 41538
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| Legacy Concept Name | Sulindac
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| type | |
| ALT_DEFINITION | A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41538
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| Accepted_Therapeutic_Use_For | Arthritis; inflammatory conditions
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0038792
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