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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C84880
http://purl.obolibrary.org/obo/NCIT_C84880
|
|---|---|
| Preferred Name | PARP Inhibitor CEP-9722 |
| Definitions |
A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA. |
|---|---|
| prefLabel | PARP Inhibitor CEP-9722
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| label | PARP Inhibitor CEP-9722
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| PDQ_Closed_Trial_Search_ID | 649505
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| code | C84880
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| Has_Target | |
| prefixIRI | NCIT:C84880
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| in_subset |
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| Display_Name | PARP Inhibitor CEP-9722
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| Preferred_Name | PARP Inhibitor CEP-9722
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| FDA_UNII_Code | B68083E4YG
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| Contributing_Source |
CTRP
FDA
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| Maps_To | PARP Inhibitor CEP-9722
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| CAS_Registry | 916574-83-9
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| NCI_Drug_Dictionary_ID | 649505
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 649505
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2827554
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