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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84879
http://purl.obolibrary.org/obo/NCIT_C84879
|
|---|---|
| Preferred Name | Iodine I 131 Iopofosine |
| Definitions |
A radioconjugate composed of iopofosine, a phospholipid ether analog, labeled with the radioactive isotope iodine I 131, with potential antineoplastic activity. Upon administration, iodine I 131 iopofosine selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD) in tumor cells compared to normal cells, thereby delivering cytotoxic radiation specifically to tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioconjugate composed of iopofosine, a phospholipid ether analog, labeled with the radioactive isotope iodine I 131, with potential antineoplastic activity. Upon administration, iodine I 131 iopofosine selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD) in tumor cells compared to normal cells, thereby delivering cytotoxic radiation specifically to tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids. |
|---|---|
| prefLabel | Iodine I 131 Iopofosine
|
| label | Iodine I 131 Iopofosine
|
| PDQ_Closed_Trial_Search_ID | 649140
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| code | C84879
|
| prefixIRI | NCIT:C84879
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| in_subset |
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| Display_Name | Iodine I 131 Iopofosine
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| Preferred_Name | Iodine I 131 Iopofosine
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| FDA_UNII_Code | R048696O9L
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Phospholipid Ether-drug Conjugate CLR 131
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| CAS_Registry | 873438-88-1
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| NCI_Drug_Dictionary_ID | 649140
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 649140
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Indicator, Reagent, or Diagnostic Aid
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| UMLS_CUI | C4045705
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