Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84871
http://purl.obolibrary.org/obo/NCIT_C84871
|
|---|---|
| Preferred Name | IGF-1R/IR Inhibitor KW-2450 |
| Definitions |
An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis. |
|---|---|
| prefLabel | IGF-1R/IR Inhibitor KW-2450
|
| label | IGF-1R/IR Inhibitor KW-2450
|
| NCI_META_CUI | CL412997
|
| PDQ_Closed_Trial_Search_ID | 648543
|
| code | C84871
|
| Has_Target | |
| prefixIRI | NCIT:C84871
|
| in_subset |
See more
See less
|
| Display_Name | IGF-1R/IR Inhibitor KW-2450
|
| Preferred_Name | IGF-1R/IR Inhibitor KW-2450
|
| FDA_UNII_Code | 2TRH1EX32K
|
| Contributing_Source |
CTRP
FDA
|
| Maps_To | IGF-1R/IR Inhibitor KW-2450
|
| CAS_Registry | 1360433-93-7
|
| NCI_Drug_Dictionary_ID | 648543
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 648543
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |