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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84858
http://purl.obolibrary.org/obo/NCIT_C84858
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|---|---|
| Preferred Name | MEK Inhibitor TAK-733 |
| Definitions |
An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. |
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| prefLabel | MEK Inhibitor TAK-733
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| label | MEK Inhibitor TAK-733
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| PDQ_Closed_Trial_Search_ID | 651550
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| code | C84858
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| Has_Target | |
| prefixIRI | NCIT:C84858
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| in_subset |
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| Display_Name | MEK Inhibitor TAK-733
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| Preferred_Name | MEK Inhibitor TAK-733
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| FDA_UNII_Code | 5J61HSP0QJ
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| Contributing_Source |
CTRP
FDA
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| Maps_To | MEK Inhibitor TAK-733
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| CAS_Registry | 1035555-63-5
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| NCI_Drug_Dictionary_ID | 651550
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 651550
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2827535
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