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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84851
http://purl.obolibrary.org/obo/NCIT_C84851
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|---|---|
| Preferred Name | Topoisomerase I Inhibitor Genz-644282 |
| Definitions |
A non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. |
|---|---|
| prefLabel | Topoisomerase I Inhibitor Genz-644282
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| label | Topoisomerase I Inhibitor Genz-644282
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| PDQ_Closed_Trial_Search_ID | 651243
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| code | C84851
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| Has_Target | |
| prefixIRI | NCIT:C84851
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| in_subset |
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| Display_Name | Topoisomerase I Inhibitor Genz-644282
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| Preferred_Name | Topoisomerase I Inhibitor Genz-644282
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| FDA_UNII_Code | 717I541I2R
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Topoisomerase I Inhibitor Genz-644282
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| CAS_Registry | 529488-28-6
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| NCI_Drug_Dictionary_ID | 651243
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 651243
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2827528
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