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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84841
http://purl.obolibrary.org/obo/NCIT_C84841
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|---|---|
| Preferred Name | PAK4 Inhibitor PF-03758309 |
| Definitions |
An orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival. |
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| prefLabel | PAK4 Inhibitor PF-03758309
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| label | PAK4 Inhibitor PF-03758309
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| NCI_META_CUI | CL412392
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| PDQ_Closed_Trial_Search_ID | 650124
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| code | C84841
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| prefixIRI | NCIT:C84841
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| in_subset |
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| Display_Name | PAK4 Inhibitor PF-03758309
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| Preferred_Name | PAK4 Inhibitor PF-03758309
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| FDA_UNII_Code | PK459EA5I2
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| Contributing_Source |
CTRP
FDA
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| Maps_To | PAK4 Inhibitor PF-03758309
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| CAS_Registry | 898044-15-0
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| NCI_Drug_Dictionary_ID | 650124
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 650124
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| Semantic_Type | Pharmacologic Substance
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