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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84840
http://purl.obolibrary.org/obo/NCIT_C84840
|
|---|---|
| Preferred Name | Oncolytic HSV1716 |
| Definitions |
A neuroattenuated, replication-restricted, ICP34.5 deleted (RL1 gene)-mutant herpes simplex virus (HSV) type I, constructed from wild-type strain 17, with potential oncolytic activity. Upon intratumoral injection, oncolytic HSV1716 transfects, replicates in, and lyses rapidly dividing cells such as tumor cells. Because the RL1 gene is deleted, HSV1716 is unable to replicate in non-dividing cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A neuroattenuated, replication-restricted, ICP34.5 deleted (RL1 gene)-mutant herpes simplex virus (HSV) type I, constructed from wild-type strain 17, with potential oncolytic activity. Upon intratumoral injection, oncolytic HSV1716 transfects, replicates in, and lyses rapidly dividing cells such as tumor cells. Because the RL1 gene is deleted, HSV1716 is unable to replicate in non-dividing cells. |
|---|---|
| prefLabel | Oncolytic HSV1716
|
| label | Oncolytic HSV1716
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| NCI_META_CUI | CL412391
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| PDQ_Closed_Trial_Search_ID | 650036
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| code | C84840
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| prefixIRI | NCIT:C84840
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| in_subset |
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| Display_Name | Oncolytic HSV1716
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| Preferred_Name | Oncolytic HSV1716
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| FDA_UNII_Code | 26WEP2905N
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Oncolytic HSV1716
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| NCI_Drug_Dictionary_ID | 650036
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 650036
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| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
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