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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84520
http://purl.obolibrary.org/obo/NCIT_C84520
|
|---|---|
| Preferred Name | Glembatumumab |
| Definitions |
A human monoclonal antibody against transmembrane glycoprotein non-metastatic melanoma protein B (GPNMB). Glembatumumab binds to GPNMB on cancer cells, but alone does not appear to inhibit cancer cell growth. However, this antibody could be utilized to deliver a conjugated cytotoxic agent to GPNMB-expressing tumor cells. GPNMB, overexpressed on the surface of various cancer cells, plays a key role in cancer cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A human monoclonal antibody against transmembrane glycoprotein non-metastatic melanoma protein B (GPNMB). Glembatumumab binds to GPNMB on cancer cells, but alone does not appear to inhibit cancer cell growth. However, this antibody could be utilized to deliver a conjugated cytotoxic agent to GPNMB-expressing tumor cells. GPNMB, overexpressed on the surface of various cancer cells, plays a key role in cancer cell proliferation. |
|---|---|
| prefLabel | Glembatumumab
|
| label | Glembatumumab
|
| code | C84520
|
| prefixIRI | NCIT:C84520
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| in_subset | |
| Preferred_Name | Glembatumumab
|
| FDA_UNII_Code | WEC7MEM1BR
|
| Contributing_Source |
FDA
PCDC
|
| CAS_Registry | 1020264-78-1
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| type | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2827489
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| Delete | Subject | Author | Type | Created |
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