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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C845
http://purl.obolibrary.org/obo/NCIT_C845
|
|---|---|
| Preferred Name | Streptozocin |
| Definitions |
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04) |
|---|---|
| prefLabel | Streptozocin
|
| label | Streptozocin
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| CHEBI_ID | CHEBI:9288
|
| PDQ_Closed_Trial_Search_ID | 42831
|
| code | C845
|
| prefixIRI | NCIT:C845
|
| in_subset | |
| Preferred_Name | Streptozocin
|
| FDA_UNII_Code | 5W494URQ81
|
| Contributing_Source | FDA
|
| Chemical_Formula | C8H15N3O7
|
| Maps_To | Streptozocin
|
| CAS_Registry | 18883-66-4
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| NSC Number | 85998
|
| NCI_Drug_Dictionary_ID | 42831
|
| Legacy Concept Name | Streptozocin
|
| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42831
|
| Accepted_Therapeutic_Use_For | Carcinoid tumor and syndrome; Colorectal cancer, palliative; Hodgkin's disease; Metastatic islet cell carcinoma of the pancreas
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0038432
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