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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C84000
http://purl.obolibrary.org/obo/NCIT_C84000
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|---|---|
| Preferred Name | Nemorubicin Hydrochloride |
| Definitions |
The hydrochloride salt form of nemorubicin, a morpholinyl analogue of the anthracycline doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450 CYP3A enzyme to a highly cytotoxic derivative. Unlike most anthracyclines, nemorubicin is a topoisomerase I inhibitor and appears to exert its effect through the nucleotide excision repair (NER) system. In addition, this agent does not show cross-resistance with other anthracyclines.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt form of nemorubicin, a morpholinyl analogue of the anthracycline doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450 CYP3A enzyme to a highly cytotoxic derivative. Unlike most anthracyclines, nemorubicin is a topoisomerase I inhibitor and appears to exert its effect through the nucleotide excision repair (NER) system. In addition, this agent does not show cross-resistance with other anthracyclines. |
|---|---|
| prefLabel | Nemorubicin Hydrochloride
|
| label | Nemorubicin Hydrochloride
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| code | C84000
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| prefixIRI | NCIT:C84000
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| in_subset | |
| Preferred_Name | Nemorubicin Hydrochloride
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| FDA_UNII_Code | 2Q6F8JYX76
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| Contributing_Source | FDA
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| Chemical_Formula | C32H37NO13.HCl
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| Maps_To | Nemorubicin Hydrochloride
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| CAS_Registry | 108943-08-4
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2827284
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