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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C83999
http://purl.obolibrary.org/obo/NCIT_C83999
|
|---|---|
| Preferred Name | Nemorubicin |
| Definitions |
A morpholinyl analogue of the anthracycline doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450 CYP3A enzyme to a highly cytotoxic derivative. Unlike most anthracyclines, nemorubicin is a topoisomerase I inhibitor and appears to exert its effect through the nucleotide excision repair (NER) system. In addition, this agent does not show cross-resistance with other anthracyclines.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A morpholinyl analogue of the anthracycline doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450 CYP3A enzyme to a highly cytotoxic derivative. Unlike most anthracyclines, nemorubicin is a topoisomerase I inhibitor and appears to exert its effect through the nucleotide excision repair (NER) system. In addition, this agent does not show cross-resistance with other anthracyclines. |
|---|---|
| label | Nemorubicin
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| prefLabel | Nemorubicin
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| in_subset | |
| Preferred_Name | Nemorubicin
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C32H37NO13
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| Maps_To | Nemorubicin
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| UMLS_CUI | C2827283
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| FDA_UNII_Code | 7618O47BQM
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| prefixIRI | NCIT:C83999
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| Contributing_Source | FDA
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| subClassOf | |
| CHEBI_ID | CHEBI:42053
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| Has_Salt_Form | |
| code | C83999
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| type | |
| Semantic_Type | Pharmacologic Substance
|
| CAS_Registry | 108852-90-0
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