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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C83819
http://purl.obolibrary.org/obo/NCIT_C83819
|
|---|---|
| Preferred Name | Efatutazone |
| Definitions |
An orally bioavailable thiazolidinedione and an agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma thus inducing cell differentiation and apoptosis, leading to a reduction in cellular proliferation. PPAR-gamma is a nuclear hormone receptor and a ligand-activated transcription factor that controls the expression of genes involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable thiazolidinedione and an agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma thus inducing cell differentiation and apoptosis, leading to a reduction in cellular proliferation. PPAR-gamma is a nuclear hormone receptor and a ligand-activated transcription factor that controls the expression of genes involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. |
|---|---|
| prefLabel | Efatutazone
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| label | Efatutazone
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| code | C83819
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| prefixIRI | NCIT:C83819
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| in_subset | |
| Preferred_Name | Efatutazone
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| FDA_UNII_Code | M17ILL71MC
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| Contributing_Source | FDA
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| Chemical_Formula | C27H26N4O4S
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| Maps_To | Efatutazone
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| CAS_Registry | 223132-37-4
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2827204
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