Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C83818
http://purl.obolibrary.org/obo/NCIT_C83818
Preferred Name

Inecalcitol
Definitions
An analog of calcitriol and a vitamin D3 receptor (VDR) agonist, with potential antineoplastic activity. Upon administration, inecalcitol targets and binds to VDR. This activates VDR and VDR-mediated signal transduction pathways. This modulates the VDR-mediated expression of certain genes, including the expression of anti-cancer genes, enhances cellular differentiation, induces tumor cell apoptosis and inhibits tumor cell growth. VDR plays a central role in calcium homeostasis and in the growth of certain cancer cells.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An analog of calcitriol and a vitamin D3 receptor (VDR) agonist, with potential antineoplastic activity. Upon administration, inecalcitol targets and binds to VDR. This activates VDR and VDR-mediated signal transduction pathways. This modulates the VDR-mediated expression of certain genes, including the expression of anti-cancer genes, enhances cellular differentiation, induces tumor cell apoptosis and inhibits tumor cell growth. VDR plays a central role in calcium homeostasis and in the growth of certain cancer cells.
prefLabel
Inecalcitol
label
Inecalcitol
PDQ_Closed_Trial_Search_ID
782341
code
C83818
Has_Target
prefixIRI
NCIT:C83818
in_subset
Display_Name
Inecalcitol
Preferred_Name
Inecalcitol
FDA_UNII_Code
05FZV98342
Contributing_Source
CTRP
FDA
Chemical_Formula
C26H40O3
Maps_To
Inecalcitol
CAS_Registry
163217-09-2
NCI_Drug_Dictionary_ID
782341
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
782341
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C2827203
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