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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C83581
http://purl.obolibrary.org/obo/NCIT_C83581
|
|---|---|
| Preferred Name | Canfosfamide |
| Definitions |
A modified glutathione analogue and nitrogen mustard prodrug, with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor cell proliferation. Glutathione S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A modified glutathione analogue and nitrogen mustard prodrug, with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor cell proliferation. Glutathione S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. |
|---|---|
| prefLabel | Canfosfamide
|
| label | Canfosfamide
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| Has_Salt_Form | |
| code | C83581
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| prefixIRI | NCIT:C83581
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| in_subset | |
| Preferred_Name | Canfosfamide
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| FDA_UNII_Code | 1RS284BFUI
|
| Contributing_Source | FDA
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| Chemical_Formula | C26H40Cl4N5O10PS
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| Maps_To | Canfosfamide
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| CAS_Registry | 158382-37-7
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0664315
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