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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C83552
http://purl.obolibrary.org/obo/NCIT_C83552
|
|---|---|
| Preferred Name | Berubicin |
| Definitions |
A 4'-O-benzylated analogue of the anthracycline derivative doxorubicin, with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, as well as RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB) and can circumvent P glycoprotein/MRP1-mediated efflux.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 4'-O-benzylated analogue of the anthracycline derivative doxorubicin, with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, as well as RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB) and can circumvent P glycoprotein/MRP1-mediated efflux. |
|---|---|
| prefLabel | Berubicin
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| label | Berubicin
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| Has_Salt_Form | |
| code | C83552
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| prefixIRI | NCIT:C83552
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| in_subset | |
| Preferred_Name | Berubicin
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| FDA_UNII_Code | 6QPN83HK2M
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| Contributing_Source | FDA
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| Chemical_Formula | C34H35NO11
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| CAS_Registry | 677017-23-1
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| type | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2827086
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